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Congresso
58th NATIONAL MEETING OF ITALIAN SOCIETY OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
lunedì 14 settembre 2015 - mercoledì, 16 settembre 2015
Università degli Studi di Urbino «Carlo Bo»
via Saffi, 42
61029 Urbino
Lunedì 14 settembre

10.30 Apertura Segreteria e Registrazione dei partecipanti
14.30-15.00 Apertura del Congresso

Saluti di benvenuto

15.00-16.00 Lettura “E. Antonini”
Chairman: Maurizio BRUNORI (Roma)
Ada YONATH (Nobel Prize for Chemistry, Weizmann, IL): “Resistance to Antibiotics and Preserving the Microbiome”

16.00-18.00 Simposio plenario “Biochemistry for an active, healthy aging”
Chairmen: Vilberto STOCCHI (Urbino), Silvana HRELIA (Bologna)
Key note speaker: Gerald I. SHULMAN (Yale University School of Medicine): “Cellular Mechanisms of Insulin Resistance: Implications for Obesity, Type 2 Diabetes and the Metabolic Syndrome”
Cristina ANGELONI (Bologna): “Neuroprotection by nutraceutical sulforaphane: a protective strategy for a healthy ageing”
Michele GUESCINI (Urbino): “The emerging role of extracellular vesicles in mediating muscle communication”
Presentazioni selezionate dagli abstract presentati
Marika COMEGNA (Napoli): “Proteomics unveils novel common genes mediating both replicative and stress-induced senescence”
Eleonora DA POZZO (Pisa): “Protection against aging in rat cardiomiocytes by Naringenin, a component of Citrus genus”
Mirko MAGNONE (Genova): “Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans”

18.00-20.00 Poster session

Welcome cocktail

Martedì 15 settembre

9.00-11.00 Simposio plenario “Frontiers in Structural Biology”
Chairmen: Menico RIZZI (Novara), Luisa BRACCI (Siena)
Key note speaker: Wolfgang BAUMEISTER (Max-Planck-Institute of Biochemistry- Martinsried): “Structural Studies of the 26 S proteasome ex situ and in situ“
Martino BOLOGNESI (Milano): “Facing Infectious Diseases through Structural Vaccinology”
Presentazioni selezionate dagli abstract presentati
Stefano RICAGNO (Milano): “Embelin binds to human neuroserpin and impairs its pathologic polymerization”
Luca Federici (Chieti): “Mapping nucleophosmin interactions for the targeted treatment of acute myeloid leukemia”

11.00-11.30 Coffee break

11.30-13.00 Simposio parallelo “New aspects in molecolar recognition”
Chairmen: Alberto PASSI (Varese), Mauro MACCARONE (Roma)
Michela TONETTI (Genova): “The glycans of large DNA viruses: a new paradigm for gycosylation”
Mauro MACCARONE (Roma): “Membrane environment as a driver of endocannabinoid signaling”
Presentazioni selezionate dagli abstract presentati
Gianluca DAMONTE (Genova): “Matrix-assisted laser desorption ionization time of flight (MALDI-TOF) analysis identifies serum angiotensin II concentrations as a strong predictor of breast cancer (BCa)-specific mortality”
Monica BORGATTIi (Ferrara): “Non-invasive prenatal testing for fetal sex determination on circulating free fetal DNA: a SPR-based approach”
Mirko PINOTTI (Ferrara): “regulation of a strong F9 cryptic 5’ss by intrinsic elements and by combination of tailored U1snRNAs with antisense oligonucleotides”
Simposio parallelo “Industrial and medical uses of enzymes”Chairmen: Loredano POLLEGGIONI (Varese), Marco MORACCI (Napoli)
Gianfranco GIRARDI (Torino): “A wedding made in heaven: Engineered monoxygenases and electrode interfaces”Elena Rosini (Varese): “Therapeutic proteins: experimental strategies for an anticancer enzyme therapy”
Presentazioni selezionate dagli abstract presentati
Stefano BRUNO (Parma): “Serine racemase: regulation by divalent cations and NADH”
Loredana MARINIELLO (Napoli): “Protein-based bioplastics crosslinked by transglutaminase”
Andrea STRAZZULLI (Napoli): “Discovering new Carbohydrate Active Enzymes for the plant biomass degradation for biorefineries: a metagenomic approach”

13.00-14.30 Lunch

14.30-16.30 Simposio plenario “Blood vessels and blood cells: from basic science to applications”
Chairmen: Federico BUSSOLINO (Torino), Mauro MAGNANI (Urbino)
Key note speaker: Vladimir MUZYKANTOV (Philadelfia, USA): “Vascular Drug Delivery using blood cells”
Alessandra BALDUINI (Pavia): “Bone marrow modeling for blood cell production”
Luca PRIMO (Torino): “Vascular branching in tumour angiogenesis”
Presentazioni selezionate dagli abstract presentati
Alessandro MALARA (Pavia): “The plant hormone absicic acid is a pro-survival agonist of mammalian megakaryocytes, the platelet progeny.”
Ferdinando MANNELLO (Urbino): “Glycosaminoglycan sulodexide: ”Janus Effect” in venous leg ulcer microenvironment”

16.30-17.00 Coffee break

17.00-18.30 Discussione Posters (Francesco BONOMI, Tonino DE FLORA, Andrea BELLELLI, Paolo PEDONE, Francesco MANCINI, Luigi PALMIERI, Mirko, PINOTTI, Paola CHIARUGI, Luca FEDERICI)

18.30-20.00 Assemblea soci SIB

Mercoledì 16 settembre

9.00-10.30 Simposio plenario “Metabolism and Computational Biology”
Chairmen: Lilia ALBERGHINA (Milano), Rita CASADIO (Bologna)
Lilia ALBERGHINA (Milano): “Systems Biology of cancer metabolic rewiring”
Andrea URBANIi (Roma): “Redefining the role of H2S in neurodegenerative disorders”

Presentazioni selezionate dagli abstract presentati
Gennaro AGRIMI (Bari): “Metabolic flux analysis of saccharomyces cerevisiae strains with an altered mitochondrial pyruvate oxidation”
Silvio TOSATTO (Padova): “Non-globular proteins: Towards an understanding of the “dark matter” in the protein universe”
Paola COCCETTI (Milano): “Glucose and Amino Acids Addiction Is a Typical Hallmark of Snf1/AMPK-Deficient Cells”
Pier Luigi MARTELLI (Bologna): “The effect of OMIM disease-related variations on protein stability: a large-scale investigation”

10.30-11.00 Coffee break

11.00-12.45 Simposio parallelo: “Vesicles trafficking and intercellular communications”
Chairmen: Vito DE PINTO (Catania), Laura MAZZANTI (Ancona)
Roberto FURLAN (Milano): “Microglial EVs: new messengers during neurological disorders”
Benedetta BUSSOLATI (Torino): “Stem cell-derived extracellular vesicles for tissue repair”
Marina PITTO (Milano): “Urinary exosomes: vescicles for biomarker trafficking”
Presentazioni selezionate dagli abstract presentati
Enrico DAINESE (Teramo): “Iron modulates the membrane-binding and the intracellular trafficking of 5-lipoxygenase: functional implications in neurodegeneration”
Italia DI LIEGRO (Palermo): “Melanoma cells release extracellular vesicle which contain H1° linker histone as well as RNA-binding proteins which bind to the H1° mRNA.”
Davide VIGETTI (Varese): “Emerging role of long non coding RNA in the regulation of hyaluronan synthesis”Simposio parallelo “Ubiquitin and ubiquitin-dependent pathways”
Chairmen: Piacentini MAURO (Roma), Marzia BIANCHI (Urbino)
BERNASSOLA Francesca (Roma): “The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukemia blasts”
PIACENTINI Mauro (Roma): “The interplay between Ambra1 and the cullin E3 ligases regulates the dynamics of autophagy”
Presentazioni selezionate dagli abstract presentati
Chiara LANZILLOTTA (Roma): “Ubiquitin-bound protein profile in human brain from Down Syndrome individuals prior and after the development of Alzheimer-like dementia.”
Rita CRINELLI (Urbino): “Proteotoxic stress, heat shock factors and Ubiquitin C gene induction: new insights into an old story”

12.45-13.45 Lunch

13.45-15.15 Simposio parallelo “Tumor cell plasticity, stem cells and therapy resistance”
Chairmen: Renza VENTO (Palermo), Roberto SCATENA (Roma)
Marta PALMIERI (Verona): “Cancer stem cells: a new frontier to understand pancreas cancer biology”
Roberto SCATENA (Roma): “Pathophysiological interrelationships between MSC and CSC. An example of cancer cell plasticity with potential clinical implications”
Presentazioni selezionate dagli abstract presentati
Daniela CAPELLO (Vercelli): “Diacylglycerol kinase alpha contributes to tumorigenicity and invasiveness of glioblastoma stem cells”
Ferdinando CHIARADONNA (Milano): “PKA activation promotes cancer cell resistance to glucose starvation and to anoikis”
Renza VENTO (Palermo): “In human osteosarcoma 3AB-OS cancer stem cells let-7d seems to have the dual function of oncogene/tumor-suppressor miRNA”
Simposio parallelo “Redox regulation of biological activities”
Chairmen: Maria CIRIOLO (Roma), Marzia PERLUIGI (Roma)
Key note speaker: Bernhard BRUNE (Università di Francoforte) “Tumor-associated macrophages – sensing and producing redox changes”
Giuseppe POLI (Torino): “Survival signaling activated by 27-hydroxycholesterol in cells of the macrophage lineage”
Presentazioni selezionate dagli abstract presentati
Barbara CAMPANINI (Parma): “CysK, a hub in the regulation of cysteine biosynthesis in E. coli”
Emmanuele DE VENDITTIS (Napoli): “Glutathione biosynthesis in a cold-adapted source”
Alessandra FRATERNALE (Urbino): “Thiol depletion and Th2 polarization: which role for pro-glutathione molecules as immunotherapeutics?”

15.15-15.30 Break

15.30-17.30 Simposio plenario: “Nanobiotechnology for diagnostic and therapeutic applications”
Chairmen: Cesare BALDUINI (Pavia), Massimo MASSERINI (Milano)
Key note speaker: Mauro FERRARI (Houston Methodist) “MultiStage Vectors and Transport Oncophysics”
Mauro MAGNANI (Urbino): “Red Blood Cells as carriers for drugs and contrasting agents”
Massimo MASSERINI (Milano): “Nanomedicine and therapy of Alzheimer disease”
Presentazioni selezionate dagli abstract presentati
Francesca RE (Milano): “Exploiting physiological proteins to drive drug-carrying nanoparticles across the blood-brain barrier”
Jlenia BRUNETTI (Siena): “Targeting Heparan Sulfate Proteoglycans by branched NT4 peptides for selective cancer imaging and therapy”
Alessandro Arcovito (Roma): “A novel approach against biofilm-growing microbial strains: functionalized virus-like particles with antimicrobial peptides”

17.30 Conclusioni e chiusura del Congresso